SOS Platform, SOS eBooks or SOS Datasets
The content of Science of Synthesis is available in three different formats. Depending on your needs, you can explore its wealth of knowledge either via the SOS Online Platform or within the SOS eBooks. Alternatively, you can use the SOS Reaction Datasets, where all the structures and reactions are in machine-readable format that can be used for cheminformatics applications, such as training algorithms.
SOS Platform: The Perfect Synthesis Solution for Your Institution
With the SOS Platform you can save time and effort by reducing the need for extensive extensive literature research. On the SOS Platform, you can quickly find the answers you are looking for. You can benefit from the comprehensive search functionality and the chemist-friendly user interface. As the content is regularly updated, newly established methods and techniques are also covered.
As well as text searching, using the built-in drawing tool, the structure/reaction search mode helps you to find potential routes to your target molecule or find out how a molecule might react further. Alternatively, you can browse through the whole platform to discover alternative options, and related reactions – perhaps giving you inspiration to try something you never would have thought of?
The SOS Platform is the perfect solution for your company, institution, or research group.
SOS eBooks: Keep Your Library Up-to-Date with SOS eBook Packages
The SOS eBook Collection comprises more than 300 volumes, covering over a century of synthetic organic chemistry. Starting from the original German “Houben-Weyl” print editions, the complete content was rewritten and revised in the English language Science of Synthesis series.
Since 2010, the “Knowledge Updates” are regularly added to supplement Science of Synthesis with new and improved methods and new product sub(classes). The “Reference Library” volumes cover the latest trends in organic chemistry and related disciplines, from electrochemistry in organic synthesis to DNA-encoded libraries.
You can purchase the SOS eBook volumes by publication year in order to keep the collection in your own library up to date. Alternatively, if you focus on a special research field, you can buy bundled topic-related packages (for example the organometallic series).
SOS Datasets: Science of Synthesis Knowledge in Machine-Readable Format
The SOS Datasets are high-quality, machine-readable structure and reaction datasets derived from the expert-curated Science of Synthesis reference work on organic and organometallic chemistry. The data contains reliable, synthesis-relevant reactions that have been selected by proven experts. The SOS Datasets can be used for the training of AI models and algorithms designed for reaction prediction and retrosynthesis.
The SOS Datasets are intended for “real-life chemists” such as process, medicinal, or synthetic organic chemists, as well as “virtual chemists” including cheminformaticians, theoretical chemists, and data scientists involved in computer-aided synthesis design and reactivity modeling.
SOS Datasets are designed to support chemical institutes and companies for training their inhouse models or supplementing existing datasets, as well as for software companies providing synthesis solutions to their customers.
Latest News from the SOS Editorial Office
Thieme Cheminars: Presented by SOS
Thieme Cheminars is a series of free-to-attend online seminars that cover topics at the forefront of chemical research. These mini-symposia are presented by Science of Synthesis and Thieme's chemistry journals.
Case Study: Synthetic Strategies toward Lactones
Take a look at this SOS case study by Yingmin Ji and Dr. Albert Granados at the Universitat Autònoma de Barcelona in Spain. It focuses on the synthesis of lactones and explains how to use SOS as a structure-based planning tool.
Thieme Has Signed National Agreement for SOS
Stuttgart: Thieme has signed a German agreement with FID Chemie – Fachinformationsdienst Chemie to provide nationwide access to Science of Synthesis, our flagship synthetic chemistry reference database.
New SOS Reference Library: Dearomatizations
The new Science of Synthesis volume "Dearomatizations", edited by David Sarlah, serves as an essential reference, covering all aspects of dearomative chemistry, from classic transformations such as the Birch reduction to cutting-edge developments in asymmetric catalysis, photochemistry, and electrochemistry.
Case Study: Discovering an Improved Synthetic Route to [1.1.1]Propellane
Check out this case study, focusing on the topic of ring-strain chemistry, from Kasmita Singha at the Indian Institute of Science (IISc) in Bangalore, and learn more about how SOS can help you in your day-to-day work.
Mariola Tortosa Becomes New SOS Board Member
We are delighted to welcome Professor Mariola Tortosa from Universidad Autónoma de Madrid (Spain) as a new member of the Science of Synthesis Editorial Board. Her research interests include boron chemistry, asymmetric catalysis and the synthesis of natural products.
New SOS: Now Online on Thieme Serve
Science of Synthesis is now available on a new platform. The new SOS makes your daily work faster and more efficient—while offering the same trusted, expert‑curated content.
Explore Modern Strategies in Organofluorine Chemistry
Jean-François Paquin is the Volume Editor of the SOS Reference Library series “Modern Strategies in Organofluorine Chemistry”. In this news, he shares an inspiring perspective on how electrochemistry is driving innovation in organofluorine chemistry.
Case Study: Enantioselective Hydroselenation of Unsaturated Hydrocarbons
Check out this case study from Chen Cui, working on organoselenium chemistry at the Beijing Institute of Technology (PR China) and learn more about how SOS can help you in your day-to-day work.
New SOS: Exclusive Sneak Preview
Science of Synthesis is moving on to a new chapter and we are excited to share a preview of what’s coming. Discover how the new, more intuitive platform will make daily work smoother, faster, and more efficient for anyone involved in organic synthesis.